منابع مشابه
Fibroblast growth factors in schizophrenia.
A large association study by O'Donovan et al recently suggested that genetic variation in fibroblast growth factor receptor (FGFR) 2 increases the risk for developing schizophrenia. Fibroblast growth factors (FGFs) are part of the family of glial growth factors; they control the growth and patterning of specific brain structures and regulate the maintenance and repair of neuronal tissues. In ad...
متن کاملFibroblast growth factors
What are they? Fibroblast growth factors (FGFs) are a family of small (20–30 kDa) intercellular signalling proteins which are frequently found to be glycosylated. The first draft of the human genome identified 29 potential FGF genes, and so far transcripts have been identified for 23 of them. Two FGFs have been identified in Caenorhabditis elegans (Let-756 and Egl-17) while Drosophila appears o...
متن کاملTargeting fibroblast growth factors in cancer
Fibroblast growth factors (FGFs) have been implicated in multiple aspects of cancer development and growth for over 20 years [1]. Research has shown that FGFs have a role in a) directly promoting cancer cell growth, b) tumor angiogenesis, and c) more speculatively, the survival of a group of cancer cells called “tumor stem cells” that are particularly difficult to target with current therapies....
متن کاملFibroblast growth factors, their receptors and signaling.
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where they can bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir,...
متن کاملFibroblast Growth Factor-1 vs. Fibroblast Growth Factor-2 in Ischemic Skin Flap Survival in a Rat Animal Model
BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2009
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbp033